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The study of Synthesis of Dihydropyrimidine for Cardiotropic Drugs Using New Catalysts on the Basis of Nano Cu Oxides
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HOME > J Korean Powder Metall Inst > Volume 12(6); 2005 > Article
신촉매 나노 구리산화물을 이용한 심혈관 의약품용 Dihydropyrimidine 제조 연구
엄영랑, 이민구, 이창규
The study of Synthesis of Dihydropyrimidine for Cardiotropic Drugs Using New Catalysts on the Basis of Nano Cu Oxides
Y. Uhm, M. Lee, C. Rhee
Journal of Korean Powder Metallurgy Institute 2005;12(6):441-446
DOI: https://doi.org/10.4150/KPMI.2005.12.6.441
1한국원자력연구소 원자려나노소재응용 LAB.
2한국원자력연구소 원자려나노소재응용 LAB.
3한국원자력연구소 원자려나노소재응용 LAB.
1Nuclear Nano Materials Development LAB., Korea Atomic Energy Research Institute(KAERI)
2Nuclear Nano Materials Development LAB., Korea Atomic Energy Research Institute(KAERI)
3Nuclear Nano Materials Development LAB., Korea Atomic Energy Research Institute(KAERI)
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The copper oxide nano powders were synthesized by levitational gas condensation (LGC) method, and were applied to catalyst to fabricate 3,4-dihydropyrimidin-2-(1H)-one. Processes of adsorption of Biginelli reaction reagents on the copper nanooxide surface Cu_2O°CuO were studied by IR-spectroscopy. It was shown that benzaldehyde coordination, acetoacetic ether on the oxide surface is carried out with participation of carbonyl fragments, urea by N-H bonds which affects positively on the reagents reactivity.

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