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2 "Detonation nanodiamond"
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Interaction of Detonation Nanodiamonds with Hispidin
Changkyu Rhee, Whungwhoe Kim, Andrey E. Burov, Alexey P. Puzyr, Vladimir S. Bondar
J Korean Powder Metall Inst. 2020;27(6):458-463.   Published online December 1, 2020
DOI: https://doi.org/10.4150/KPMI.2020.27.6.458
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Hispidin is a secondary metabolite found in numerous medicinal mushrooms that has attracted significant attention, owing to its distinct biological effects, including antioxidant, anti-inflammatory, antitumor, and cytoprotective properties. Experiments are being carried out to study the interaction of detonation nanodiamonds (DNDs) with synthetic and natural hispidin sourced from extracts of Pholiota sp. fungus. The bioluminescence method is used to determine the adsorption/ desorption properties of DNDs toward hispidin. It is found that hispidin forms strong conjugates with DNDs, and the use of various eluents does not result in a significant release of the adsorbed hispidin molecules. DND-bovine serum albumin (BSA) complex, where DNDs serve as a carrier for the protein and the latter acts as a hispidin sorbent, has been developed and applied in hispidin adsorption/desorption tests. The results support the use of the DNDs as a carrier for hispidin in medical applications. They also advocate the application of the DND-BSA complex for isolating the substance from fungal extracts.

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Nanodiamonds Conjugated with Nonsteroidal Anti-inflammatory Drugs for Transdermal Delivery
Changkyu Rhee, Alexey P. Puzyr, Andrey E. Burov, Olga G. Burova, Whungwhoe Kim, Vladimir S. Bondar
J Korean Powder Metall Inst. 2018;25(6):459-465.   Published online December 1, 2018
DOI: https://doi.org/10.4150/KPMI.2018.25.6.459
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Most commercially available detonation nanodiamonds (DNDs) require further processing to qualify for use in biomedical applications, as they often contain many impurities and exhibit poor dispersibility in aqueous media. In this work, DNDs are modified to improve purity and impart a high colloidal stability to the particles. The dispersive and adsorption properties of modified DNDs are evaluated in terms of the suitability of DNDs as carriers for non-steroidal anti-inflammatory drugs (NSAIDs) in transdermal delivery. The study of adsorption on strongly positively and strongly negatively charged DNDs showed their high loading capacity for NSAIDs, and a pronounced relationship between the drugs and the particles’ charges. Experiments on long-term desorption carried out with DND/NSAID complexes indicate that the nanoparticles exert a sustained effect on the drug release process.


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